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3kxt

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Template:STRUCTURE 3kxt

Contents

Crystal structure of Sulfolobus Cren7-dsDNA complex

Template:ABSTRACT PUBMED 20512977

Function

[CREN7_SULSO] A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly.[1]

About this Structure

3kxt is a 3 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

  • Feng Y, Yao H, Wang J. Crystal structure of the crenarchaeal conserved chromatin protein Cren7 and double-stranded DNA complex. Protein Sci. 2010 Jun;19(6):1253-7. PMID:20512977 doi:10.1002/pro.385
  1. ↑ Guo L, Feng Y, Zhang Z, Yao H, Luo Y, Wang J, Huang L. Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. Nucleic Acids Res. 2008 Mar;36(4):1129-37. Epub 2007 Dec 20. PMID:18096617 doi:10.1093/nar/gkm1128

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