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3nd2

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Template:STRUCTURE 3nd2

Contents

Structure of Yeast Importin-beta (Kap95p)

Template:ABSTRACT PUBMED 20826343

Function

[IMB1_YEAST] Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B.[1]

About this Structure

3nd2 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Forwood JK, Lange A, Zachariae U, Marfori M, Preast C, Grubmuller H, Stewart M, Corbett AH, Kobe B. Quantitative structural analysis of importin-beta flexibility: paradigm for solenoid protein structures. Structure. 2010 Sep 8;18(9):1171-83. PMID:20826343 doi:10.1016/j.str.2010.06.015
  1. ↑ Mosammaparast N, Jackson KR, Guo Y, Brame CJ, Shabanowitz J, Hunt DF, Pemberton LF. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J Cell Biol. 2001 Apr 16;153(2):251-62. PMID:11309407

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