3juv
From Proteopedia
Contents |
Crystal structure of human lanosterol 14alpha-demethylase (CYP51)
Template:ABSTRACT PUBMED 020149798
Function
[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
About this Structure
3juv is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075
Categories: Homo sapiens | Sterol 14-demethylase | Arrowsmith, C H. | Bountra, C. | Edwards, A M. | MacKenzie, F. | Park, H. | SGC, Structural Genomics Consortium. | Strushkevich, N. | Usanov, S A. | Weigelt, J. | Cholesterol biosynthesis | Cytochrome p450 | Endoplasmic reticulum | Heme | Iron | Lipid synthesis | Membrane | Metal-binding | Microsome | Monooxygenase | Nadp | Oxidoreductase | Sgc | Steroid biosynthesis | Sterol 14alpha-demethylase | Sterol biosynthesis | Structural genomic | Structural genomics consortium | Transmembrane
