3lb6

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Template:STRUCTURE 3lb6

Contents 1 The structure of IL-13 in complex with IL-13Ralpha2 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

The structure of IL-13 in complex with IL-13Ralpha2

Template:ABSTRACT PUBMED 20223216

Disease

[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Function

[A8K7E2_HUMAN] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).^[1] [IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

About this Structure

3lb6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Interleukin
• Interleukin receptor

Reference

• Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010 Mar 10;18(3):332-42. PMID:20223216 doi:10.1016/j.str.2010.01.003

1. ↑ Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010 Mar 10;18(3):332-42. PMID:20223216 doi:10.1016/j.str.2010.01.003