3kzd

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Template:STRUCTURE 3kzd

Contents

Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain

Template:ABSTRACT PUBMED 20361982

Function

[TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

About this Structure

3kzd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol. 2010 May 21;398(5):730-46. Epub 2010 Mar 31. PMID:20361982 doi:10.1016/j.jmb.2010.03.047

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