3le7

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Template:STRUCTURE 3le7

Contents 1 Crystal structure of PD-L1 from P. dioica in complex with adenine 2 Function 3 About this Structure 4 Reference

Crystal structure of PD-L1 from P. dioica in complex with adenine

Template:ABSTRACT PUBMED 20174685

Function

[RIPL1_PHYDI] Inhibits protein synthesis. Cleaves supercoiled pBR322 dsDNA.^{[1] [2]}

About this Structure

3le7 is a 2 chain structure with sequence from Phytolacca dioica. Full crystallographic information is available from OCA.

Reference

• Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A. The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves. Mol Biosyst. 2010 Mar;6(3):570-9. Epub 2010 Jan 21. PMID:20174685 doi:10.1039/b919801f

1. ↑ Di Maro A, Valbonesi P, Bolognesi A, Stirpe F, De Luca P, Siniscalco Gigliano G, Gaudio L, Delli Bovi P, Ferranti P, Malorni A, Parente A. Isolation and characterization of four type-1 ribosome-inactivating proteins, with polynucleotide:adenosine glycosidase activity, from leaves of Phytolacca dioica L. Planta. 1999 Mar;208(1):125-31. PMID:10213004
2. ↑ Aceto S, Di Maro A, Conforto B, Siniscalco GG, Parente A, Delli Bovi P, Gaudio L. Nicking activity on pBR322 DNA of ribosome inactivating proteins from Phytolacca dioica L. leaves. Biol Chem. 2005 Apr;386(4):307-17. PMID:15899692 doi:10.1515/BC.2005.037