3ks4
From Proteopedia
Contents |
Crystal structure of Reston ebolavirus VP35 RNA binding domain
Template:ABSTRACT PUBMED 20018665
Function
[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
About this Structure
3ks4 is a 2 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.
Reference
- Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, Macrae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2009 Dec 14. PMID:20018665
Categories: Reston ebolavirus | Bornholdt, Z A. | Kimberlin, C R. | Li, S. | Macrae, I J. | Saphire, E O. | Woods, V L. | Ebolavirus | Host cytoplasm | Interferon | Interferon antiviral system evasion | Protein-rna complex | Reston | Rna binding protein | Rna replication | Rna-binding | Rna-binding protein | Transcription | Viral protein | Virion
