3nft

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Template:STRUCTURE 3nft

Contents 1 Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei 2 Function 3 About this Structure 4 Reference

Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei

Template:ABSTRACT PUBMED 20823511

Function

[BIPD_BURPS] Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane.^{[1] [2]}

About this Structure

3nft is a 1 chain structure with sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.

Reference

• Pal M, Erskine PT, Gill RS, Wood SP, Cooper JB. Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):990-3. Epub 2010 Aug 21. PMID:20823511 doi:10.1107/S1744309110026333

1. ↑ Stevens MP, Wood MW, Taylor LA, Monaghan P, Hawes P, Jones PW, Wallis TS, Galyov EE. An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen. Mol Microbiol. 2002 Nov;46(3):649-59. PMID:12410823
2. ↑ Stevens MP, Haque A, Atkins T, Hill J, Wood MW, Easton A, Nelson M, Underwood-Fowler C, Titball RW, Bancroft GJ, Galyov EE. Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis. Microbiology. 2004 Aug;150(Pt 8):2669-76. PMID:15289563 doi:10.1099/mic.0.27146-0