3m1h

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Template:STRUCTURE 3m1h

Contents

Crystal Structure Analysis of the K3 Cleaved Adhesin Domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis w83

Template:ABSTRACT PUBMED 21812842

Function

[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]

About this Structure

3m1h is a 4 chain structure with sequence from Porphyromonas gingivalis w83. Full crystallographic information is available from OCA.

Reference

  • Li N, Yun P, Jeffries CM, Langley D, Gamsjaeger R, Church WB, Hunter N, Collyer CA. The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Mol Microbiol. 2011 Sep;81(5):1358-73. doi: 10.1111/j.1365-2958.2011.07768.x., Epub 2011 Aug 4. PMID:21812842 doi:10.1111/j.1365-2958.2011.07768.x

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