3k4e

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Template:STRUCTURE 3k4e

Contents

Puf3 RNA binding domain bound to Cox17 RNA 3' UTR recognition sequence site A

Template:ABSTRACT PUBMED 19918084

Function

[PUF3_YEAST] RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology.[1] [2] [3] [4] [5] [6] [7]

About this Structure

3k4e is a 6 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Zhu D, Stumpf CR, Krahn JM, Wickens M, Hall TM. A 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20192-7. Epub 2009 Nov 16. PMID:19918084 doi:10.1073/pnas.0812079106
  1. ↑ Olivas W, Parker R. The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J. 2000 Dec 1;19(23):6602-11. PMID:11101532 doi:10.1093/emboj/19.23.6602
  2. ↑ Jackson JS Jr, Houshmandi SS, Lopez Leban F, Olivas WM. Recruitment of the Puf3 protein to its mRNA target for regulation of mRNA decay in yeast. RNA. 2004 Oct;10(10):1625-36. Epub 2004 Aug 30. PMID:15337848 doi:10.1261/rna.7270204
  3. ↑ Ringner M, Krogh M. Folding free energies of 5'-UTRs impact post-transcriptional regulation on a genomic scale in yeast. PLoS Comput Biol. 2005 Dec;1(7):e72. Epub 2005 Dec 9. PMID:16355254 doi:10.1371/journal.pcbi.0010072
  4. ↑ Houshmandi SS, Olivas WM. Yeast Puf3 mutants reveal the complexity of Puf-RNA binding and identify a loop required for regulation of mRNA decay. RNA. 2005 Nov;11(11):1655-66. PMID:16244132 doi:10.1261/rna.2168505
  5. ↑ Garcia-Rodriguez LJ, Gay AC, Pon LA. Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast. J Cell Biol. 2007 Jan 15;176(2):197-207. Epub 2007 Jan 8. PMID:17210948 doi:10.1083/jcb.200606054
  6. ↑ Saint-Georges Y, Garcia M, Delaveau T, Jourdren L, Le Crom S, Lemoine S, Tanty V, Devaux F, Jacq C. Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localization. PLoS One. 2008 Jun 4;3(6):e2293. doi: 10.1371/journal.pone.0002293. PMID:18523582 doi:10.1371/journal.pone.0002293
  7. ↑ Ulbricht RJ, Olivas WM. Puf1p acts in combination with other yeast Puf proteins to control mRNA stability. RNA. 2008 Feb;14(2):246-62. Epub 2007 Dec 19. PMID:18094119 doi:10.1261/rna.847408

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