3l2y

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Template:STRUCTURE 3l2y

Contents

The structure of C-reactive protein bound to phosphoethanolamine

Template:ABSTRACT PUBMED 21360619

Function

[CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

About this Structure

3l2y is a 20 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mikolajek H, Kolstoe SE, Pye VE, Mangione P, Pepys MB, Wood SP. Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. J Mol Recognit. 2011 Mar;24(2):371-7. doi: 10.1002/jmr.1090. PMID:21360619 doi:10.1002/jmr.1090

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OCA

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