3ksq

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Template:STRUCTURE 3ksq

Contents

Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors

Template:ABSTRACT PUBMED 20056542

Function

[FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

About this Structure

3ksq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Zhu HY, Cooper AB, Desai J, Njoroge G, Kirschmeier P, Bishop WR, Strickland C, Hruza A, Doll RJ, Girijavallabhan VM. Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1134-6. Epub 2009 Dec 6. PMID:20056542 doi:10.1016/j.bmcl.2009.12.013

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