1qo8

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Image:1qo8.gif

1qo8, resolution 2.15Å

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THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE

Overview

Fumarate reductases and succinate dehydrogenases play central roles in the metabolism of eukaryotic and prokaryotic cells. A recent medium resolution structure of the Escherichia coli fumarate reductase (Frd) has revealed the overall organization of the membrane-bound complex. Here we present the first high resolution X-ray crystal structure of a water-soluble bacterial fumarate reductase in an open conformation. This structure reveals a mobile domain that modulates substrate access to the active site and provides new insights into the mechanism of this widespread and important family of FAD-containing respiratory proteins.

About this Structure

1QO8 is a Single protein structure of sequence from Shewanella frigidimarina with and as ligands. Active as Succinate dehydrogenase, with EC number 1.3.99.1 Known structural/functional Sites: , , , , , , , , and . Full crystallographic information is available from OCA.

Reference

Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549

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