3n4q

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Template:STRUCTURE 3n4q

Contents

Human cytomegalovirus terminase nuclease domain, Mn soaked

Template:ABSTRACT PUBMED 20805464

Function

[TERL_HCMVA] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation (By similarity).

About this Structure

3n4q is a 4 chain structure with sequence from Human herpesvirus 5. Full crystallographic information is available from OCA.

Reference

  • Nadal M, Mas PJ, Blanco AG, Arnan C, Sola M, Hart DJ, Coll M. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16078-83. Epub 2010 Aug 30. PMID:20805464 doi:10.1073/pnas.1007144107

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