3mi7

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Template:STRUCTURE 3mi7

Contents 1 An Enhanced Repressor of Human Papillomavirus E2 Protein 2 Function 3 About this Structure 4 Reference

An Enhanced Repressor of Human Papillomavirus E2 Protein

Template:ABSTRACT PUBMED 21482558

Function

[VE2_HPV16] Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.^{[1] [2] [3]}

About this Structure

3mi7 is a 1 chain structure with sequence from Human papillomavirus type 16. Full crystallographic information is available from OCA.

Reference

• Bose K, Meinke G, Bohm A, Baleja JD. Design and characterization of an enhanced repressor of human papillomavirus E2 protein. FASEB J. 2011 Jul;25(7):2354-61. Epub 2011 Apr 11. PMID:21482558 doi:10.1096/fj.10-176461

1. ↑ Phelps WC, Howley PM. Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product. J Virol. 1987 May;61(5):1630-8. PMID:3033289
2. ↑ Del Vecchio AM, Romanczuk H, Howley PM, Baker CC. Transient replication of human papillomavirus DNAs. J Virol. 1992 Oct;66(10):5949-58. PMID:1326651
3. ↑ Okoye A, Cordano P, Taylor ER, Morgan IM, Everett R, Campo MS. Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2. Virus Res. 2005 Mar;108(1-2):1-14. PMID:15681049 doi:10.1016/j.virusres.2004.07.004