3k3e

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Template:STRUCTURE 3k3e

Contents 1 Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691

Template:ABSTRACT PUBMED 20121115

Function

[PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.^[1]

About this Structure

3k3e is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

• Phosphodiesterase

Reference

• Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis. J Med Chem. 2010 Feb 1. PMID:20121115 doi:10.1021/jm901519f

1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755