3nfq

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Template:STRUCTURE 3nfq

Contents 1 Crystal structure of the conserved central domain of yeast Spn1/Iws1 2 Function 3 About this Structure 4 Reference

Crystal structure of the conserved central domain of yeast Spn1/Iws1

Template:ABSTRACT PUBMED 20875428

Function

[IWS1_YEAST] Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.^{[1] [2]}

About this Structure

3nfq is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

• Pujari V, Radebaugh CA, Chodaparambil JV, Muthurajan UM, Almeida AR, Fischbeck JA, Luger K, Stargell LA. The Transcription Factor Spn1 Regulates Gene Expression via a Highly Conserved Novel Structural Motif. J Mol Biol. 2010 Sep 25. PMID:20875428 doi:10.1016/j.jmb.2010.09.040

1. ↑ Fischbeck JA, Kraemer SM, Stargell LA. SPN1, a conserved gene identified by suppression of a postrecruitment-defective yeast TATA-binding protein mutant. Genetics. 2002 Dec;162(4):1605-16. PMID:12524336
2. ↑ Lindstrom DL, Squazzo SL, Muster N, Burckin TA, Wachter KC, Emigh CA, McCleery JA, Yates JR 3rd, Hartzog GA. Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol. 2003 Feb;23(4):1368-78. PMID:12556496