3nzz

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Template:STRUCTURE 3nzz

Contents 1 Crystal Structure of the Salmonella Type III Secretion System Tip Protein SipD 2 Function 3 About this Structure 4 Reference

Crystal Structure of the Salmonella Type III Secretion System Tip Protein SipD

Template:ABSTRACT PUBMED 21031487

Function

[SIPD_SALTY] Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.^{[1] [2]}

About this Structure

3nzz is a 2 chain structure with sequence from Salmonella enterica. Full crystallographic information is available from OCA.

Reference

• Chatterjee S, Zhong D, Nordhues BA, Battaile KP, Lovell SW, De Guzman RN. The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci. 2010 Oct 28. PMID:21031487 doi:10.1002/pro.537

1. ↑ Kaniga K, Trollinger D, Galan JE. Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins. J Bacteriol. 1995 Dec;177(24):7078-85. PMID:8522512
2. ↑ Collazo CM, Galan JE. The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Mol Microbiol. 1997 May;24(4):747-56. PMID:9194702