3pdx

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Template:STRUCTURE 3pdx

Contents

Crystal structural of mouse tyrosine aminotransferase

Template:ABSTRACT PUBMED 21153519

Function

[ATTY_MOUSE] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine.

About this Structure

3pdx is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Mehere P, Han Q, Lemkul JA, Vavricka CJ, Robinson H, Bevan DR, Li J. Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations. Protein Cell. 2010 Nov;1(11):1023-32. Epub 2010 Dec 10. PMID:21153519 doi:10.1007/s13238-010-0128-5

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