3orc

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Template:STRUCTURE 3orc

Contents

CRYSTAL STRUCTURE OF AN ENGINEERED CRO MONOMER BOUND NONSPECIFICALLY TO DNA

Template:ABSTRACT PUBMED 9684880

Function

[RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.

About this Structure

3orc is a 3 chain structure with sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

  • Albright RA, Mossing MC, Matthews BW. Crystal structure of an engineered Cro monomer bound nonspecifically to DNA: possible implications for nonspecific binding by the wild-type protein. Protein Sci. 1998 Jul;7(7):1485-94. PMID:9684880

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