3pge

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Template:STRUCTURE 3pge

Contents

Structure of sumoylated PCNA

Template:ABSTRACT PUBMED 21167178

Function

[SMT3_YEAST] Not known; suppressor of MIF2 mutations. [PCNA_YEAST] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.[1] [2]

About this Structure

3pge is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Freudenthal BD, Brogie JE, Gakhar L, Kondratick CM, Washington MT. Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen. J Mol Biol. 2010 Dec 15. PMID:21167178 doi:10.1016/j.jmb.2010.12.015
  1. ↑ Haracska L, Kondratick CM, Unk I, Prakash S, Prakash L. Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell. 2001 Aug;8(2):407-15. PMID:11545742
  2. ↑ Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 2002 Sep 12;419(6903):135-41. PMID:12226657 doi:10.1038/nature00991

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