3o8a

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Template:STRUCTURE 3o8a

Contents 1 Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348

Template:ABSTRACT PUBMED 20702404

Function

[PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

About this Structure

3o8a is a 1 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

• Dihydroorotate dehydrogenase

Reference

• Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22;285(43):33054-64. Epub 2010 Aug 11. PMID:20702404 doi:10.1074/jbc.M110.162081