3o87

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Template:STRUCTURE 3o87

Contents 1 Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor 2 Function 3 About this Structure 4 Reference

Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor

Template:ABSTRACT PUBMED 20945905

Function

[AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

About this Structure

3o87 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Eidam O, Romagnoli C, Caselli E, Babaoglu K, Pohlhaus DT, Karpiak J, Bonnet R, Shoichet BK, Prati F. Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors. J Med Chem. 2010 Oct 14. PMID:20945905 doi:10.1021/jm101015z