3qnj
From Proteopedia
Contents |
Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin
Function
[DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
About this Structure
3qnj is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Knappe D, Zahn M, Sauer U, Schiffer G, Strater N, Hoffmann R. Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex. Chembiochem. 2011 Mar 8. doi: 10.1002/cbic.201000792. PMID:21387510 doi:10.1002/cbic.201000792
