3rq3
From Proteopedia
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form
Function
[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
About this Structure
3rq3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Almo, S C. | Guo, H. | IFN, Atoms-to-Animals:.The Immune Function Network. | NYSGRC, New York Structural Genomics Research Consortium. | Nathenson, S G. | Ramagopal, U A. | Rubinstein, R. | Samanta, D. | Adhesion | Atoms-to-animals: the immune function network | Ifn | Ig-domain | Immune receptor | Immune system | New york structural genomics research consortium | Nysgrc | Psi-biology | Structural genomic | Tigit
