3s24

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Template:STRUCTURE 3s24

Contents 1 Crystal structure of human mRNA guanylyltransferase 2 Function 3 About this Structure 4 Reference

Crystal structure of human mRNA guanylyltransferase

Template:ABSTRACT PUBMED 21636784

Function

[MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.

About this Structure

3s24 is a 7 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proc Natl Acad Sci U S A. 2011 Jun 2. PMID:21636784 doi:10.1073/pnas.1106610108