3qj4
From Proteopedia
Contents |
Crystal structure of Human Renalase (isoform 1)
Template:ABSTRACT PUBMED 21699903
Function
[RNLS_HUMAN] Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.[1] [2]
About this Structure
3qj4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Milani M, Ciriello F, Baroni S, Pandini V, Canevari G, Bolognesi M, Aliverti A. FAD-Binding Site and NADP Reactivity in Human Renalase: A New Enzyme Involved in Blood Pressure Regulation. J Mol Biol. 2011 Jun 14. PMID:21699903 doi:10.1016/j.jmb.2011.06.010
- ↑ Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7. PMID:15841207 doi:10.1172/JCI24066
- ↑ Boomsma F, Tipton KF. Renalase, a catecholamine-metabolising enzyme? J Neural Transm. 2007;114(6):775-6. Epub 2007 Mar 26. PMID:17385068 doi:10.1007/s00702-007-0672-1
