3qe6

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Template:STRUCTURE 3qe6

Contents

Mouse PACSIN 3 F-BAR domain structure

Template:ABSTRACT PUBMED 22573331

Function

[PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

About this Structure

3qe6 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Bai X, Meng G, Luo M, Zheng X. The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules. J Biol Chem. 2012 May 9. PMID:22573331 doi:10.1074/jbc.M112.358960

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