3poa

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3poa

Contents 1 Structural and functional analysis of phosphothreonine-dependent FHA domain interactions 2 Function 3 About this Structure 4 Reference

Structural and functional analysis of phosphothreonine-dependent FHA domain interactions

Template:ABSTRACT PUBMED 21134638

Function

[P71590_MYCTU] Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis.^[1]

About this Structure

3poa is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

• Pennell S, Westcott S, Ortiz-Lombardia M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ. Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure. 2010 Dec 8;18(12):1587-95. PMID:21134638 doi:10.1016/j.str.2010.09.014

1. ↑ Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24;5(208):ra7. PMID:22275220 doi:10.1126/scisignal.2002525