3rfh

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Template:STRUCTURE 3rfh

Contents

Crystal structure of the yeast RACK1 dimer in space group P21

Template:ABSTRACT PUBMED 21704636

Function

[GBLP_YEAST] Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins.[1]

About this Structure

3rfh is a 4 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Yatime L, Hein KL, Nilsson J, Nissen P. Structure of the RACK1 dimer from Saccharomyces cerevisiae. J Mol Biol. 2011 Aug 12;411(2):486-98. Epub 2011 Jun 17. PMID:21704636 doi:10.1016/j.jmb.2011.06.017
  1. ↑ Gerbasi VR, Weaver CM, Hill S, Friedman DB, Link AJ. Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression. Mol Cell Biol. 2004 Sep;24(18):8276-87. PMID:15340087 doi:10.1128/MCB.24.18.8276-8287.2004

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