3qg2

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Template:STRUCTURE 3qg2

Contents

Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex

Template:ABSTRACT PUBMED 21650210

Function

[D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

3qg2 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

  • Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y. Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance. ACS Chem Biol. 2011 Jun 16. PMID:21650210 doi:10.1021/cb200124r

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OCA

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