3rbg

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Template:STRUCTURE 3rbg

Contents 1 Crystal structure analysis of Class-I MHC restricted T-cell associated molecule 2 Function 3 About this Structure 4 Reference

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

Template:ABSTRACT PUBMED 23583034

Function

[CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.^[1] [UniProtKB:Q149L7]

About this Structure

3rbg is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A. Functional classification of immune regulatory proteins. Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034 doi:10.1016/j.str.2013.02.022

1. ↑ Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86. Epub 2005 Apr 5. PMID:15811952 doi:10.1182/blood-2005-02-0817