3snf

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Template:STRUCTURE 3snf

Contents

Onconase, atomic resolution crystal structure

Template:ABSTRACT PUBMED 21895975

Function

[RNP30_RANPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.

About this Structure

3snf is a 1 chain structure with sequence from Rana pipiens. Full crystallographic information is available from OCA.

Reference

  • Holloway DE, Singh UP, Shogen K, Acharya KR. Crystal structure of Onconase at 1.1 A resolution--insights into substrate binding and collective motion. FEBS J. 2011 Nov;278(21):4136-49. doi: 10.1111/j.1742-4658.2011.08320.x. Epub, 2011 Sep 28. PMID:21895975 doi:10.1111/j.1742-4658.2011.08320.x

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OCA

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