3tvd
From Proteopedia
Contents |
Crystal Structure of Mouse RhoA-GTP complex
Template:ABSTRACT PUBMED 23001747
Function
[RHOA_RAT] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
About this Structure
3tvd is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Jobichen C, Pal K, Swaminathan K. Crystal structure of mouse RhoA:GTPgammaS complex in a centered lattice. J Struct Funct Genomics. 2012 Sep 22. PMID:23001747 doi:10.1007/s10969-012-9143-5
