2xqq

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Template:STRUCTURE 2xqq

Contents

Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide (Ac-SRGTQTE).

Template:ABSTRACT PUBMED 21533121

Function

[DYL2_HUMAN] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

About this Structure

2xqq is a 8 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Rapali P, Radnai L, Suveges D, Harmat V, Tolgyesi F, Wahlgren WY, Katona G, Nyitray L, Pal G. Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. PLoS One. 2011 Apr 18;6(4):e18818. PMID:21533121 doi:10.1371/journal.pone.0018818

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OCA

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