3u2c

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Template:STRUCTURE 3u2c

Contents 1 Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution 2 Function 3 About this Structure 4 See Also 5 Reference

Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution

Function

[ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

About this Structure

3u2c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Aldose Reductase

Reference

• Steuber H. An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 A Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects. ChemMedChem. 2011 Oct 13. doi: 10.1002/cmdc.201100374. PMID:21997888 doi:10.1002/cmdc.201100374