3w0d

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Template:STRUCTURE 3w0d

Contents

Structure of elastase inhibitor AFUEI (cyrstal form I)

Template:ABSTRACT PUBMED 23640894

Function

[IELA_ASPFU] Elastase inhibitor. Non-competitive inhibitor of A.fumigatus elastase with a Ki of 1.6 nM. Inhibits the fibrinogenase and collagenase activities of A.fumigatus elastase. Inhibitor of A.flavus elastase and human leukocyte elastase, and weakly inhibits porcine pancreatic elastase. Does not inhibit elastase from P.aeruginosa or C.atrox venom.

About this Structure

3w0d is a 2 chain structure with sequence from Aspergillus fumigatus af293. Full crystallographic information is available from OCA.

Reference

  • Sakuma M, Imada K, Okumura Y, Uchiya KI, Yamashita N, Ogawa K, Hijikata A, Shirai T, Homma M, Nikai T. X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus. J Biol Chem. 2013 May 2. PMID:23640894 doi:10.1074/jbc.M112.433987

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