3so5

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3so5

Contents 1 Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution 2 Function 3 About this Structure 4 Reference

Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution

Function

[LRIG3_MOUSE] Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.^{[1] [2]}

About this Structure

3so5 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

1. ↑ Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9. doi: 10.1242/dev.029330. Epub 2008 Nov 12. PMID:19004851 doi:10.1242/dev.029330
2. ↑ Abraira VE, Satoh T, Fekete DM, Goodrich LV. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. PLoS One. 2010 Feb 1;5(2):e8981. doi: 10.1371/journal.pone.0008981. PMID:20126551 doi:10.1371/journal.pone.0008981