3tmk

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Template:STRUCTURE 3tmk

Contents 1 CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION 2 Function 3 About this Structure 4 See Also 5 Reference

CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION

Template:ABSTRACT PUBMED 9521686

Function

[KTHY_YEAST] Catalyzes the conversion of dTMP to dTDP.

About this Structure

3tmk is a 8 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

• Thymidylate kinase

Reference

• Lavie A, Konrad M, Brundiers R, Goody RS, Schlichting I, Reinstein J. Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation. Biochemistry. 1998 Mar 17;37(11):3677-86. PMID:9521686 doi:10.1021/bi9720787