3ums

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Template:STRUCTURE 3ums

Contents 1 Crystal structure of the G202A mutant of human G-alpha-i1 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of the G202A mutant of human G-alpha-i1

Template:ABSTRACT PUBMED 20351284

Function

[GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.^{[1] [2]}

About this Structure

3ums is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2pz2. Full crystallographic information is available from OCA.

See Also

• Guanine nucleotide-binding protein

Reference

• Lambert NA, Johnston CA, Cappell SD, Kuravi S, Kimple AJ, Willard FS, Siderovski DP. Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7066-71. Epub 2010 Mar 29. PMID:20351284 doi:10.1073/pnas.0912934107

1. ↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
2. ↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214