4b20
From Proteopedia
Contents |
Structural basis of DNA loop recognition by Endonuclease V
Template:ABSTRACT PUBMED 23313664
Function
[NFI_THEMA] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro).[1]
About this Structure
4b20 is a 6 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
