4de5
From Proteopedia
Contents |
Pantothenate synthetase in complex with fragment 6
Template:ABSTRACT PUBMED 23872845
Function
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this Structure
4de5 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc Natl Acad Sci U S A. 2013 Jul 19. PMID:23872845 doi:10.1073/pnas.1304045110
- ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627
Categories: Mycobacterium tuberculosis | Pantoate--beta-alanine ligase | Silvestre, H L. | Alpha beta/adenine nucleotide alpha hydrolase-like | Fragment-based drug discovery | Ligase-ligase inhibitor complex | Pantoate and b-ala binding | Pantoate-beta-alanine ligase | Protein in complex with fragment
