4b48

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Template:STRUCTURE 4b48

Contents

Bacterial translation initiation factor IF2 (1-363), complex with GTP

Template:ABSTRACT PUBMED 23695237

Function

[IF2_THET8] One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

About this Structure

4b48 is a 1 chain structure with sequence from Thermus thermophilus hb8. Full crystallographic information is available from OCA.

Reference

  • Simonetti A, Marzi S, Fabbretti A, Hazemann I, Jenner L, Urzhumtsev A, Gualerzi CO, Klaholz BP. Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):925-33. doi:, 10.1107/S0907444913006422. Epub 2013 Apr 23. PMID:23695237 doi:10.1107/S0907444913006422

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