3zko

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Template:STRUCTURE 3zko

Contents

The structure of breathing dengue virus.

Template:ABSTRACT PUBMED 23637405

Function

[Q66394_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]

About this Structure

3zko is a 3 chain structure with sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

  • Fibriansah G, Ng TS, Kostyuchenko VA, Lee J, Lee S, Wang J, Lok SM. Structural changes of dengue virus when exposed to 37{degrees}C. J Virol. 2013 May 1. PMID:23637405 doi:10.1128/JVI.00757-13

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