4bof

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Template:STRUCTURE 4bof

Contents

Crystal structure of arginine deiminase from group A streptococcus

Template:ABSTRACT PUBMED 23919999

Function

[ARCA_STRPY] Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).[HAMAP-Rule:MF_00242]

About this Structure

4bof is a 8 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

  • Henningham A, Ericsson DJ, Langer K, Casey LW, Jovcevski B, Chhatwal GS, Aquilina JA, Batzloff MR, Kobe B, Walker MJ. Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. MBio. 2013 Aug 6;4(4). pii: e00509-13. doi: 10.1128/mBio.00509-13. PMID:23919999 doi:10.1128/mBio.00509-13

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