4a6e

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Template:STRUCTURE 4a6e

Contents

Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM and N-acetylserotonin

Template:ABSTRACT PUBMED 22775292

Function

[ASMT_HUMAN] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.[1]

About this Structure

4a6e is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x
  1. ↑ Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x

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