4a6d

From Proteopedia

Revision as of 05:10, 28 August 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 4a6d

Contents

Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM

Template:ABSTRACT PUBMED 22775292

Function

[ASMT_HUMAN] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.[1]

About this Structure

4a6d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x
  1. ↑ Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4a6d"
Personal tools