3zgc
From Proteopedia
Contents |
crystal structure of the KEAP1-NEH2 complex
Template:ABSTRACT PUBMED 23722832
Function
[NF2L2_HUMAN] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.[1]
About this Structure
3zgc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Horer S, Reinert D, Ostmann K, Hoevels Y, Nar H. Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):592-6. doi:, 10.1107/S174430911301124X. Epub 2013 May 23. PMID:23722832 doi:10.1107/S174430911301124X
- ↑ Huang HC, Nguyen T, Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12475-80. PMID:11035812 doi:http://dx.doi.org/10.1073/pnas.220418997
