4c0a

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Template:STRUCTURE 4c0a

Contents

Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain

Template:ABSTRACT PUBMED 24058294

Function

[ARF1_BOVIN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.

About this Structure

4c0a is a 8 chain structure with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Aizel K, Biou V, Navaza J, Duarte LV, Campanacci V, Cherfils J, Zeghouf M. Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2. PLoS Biol. 2013 Sep;11(9):e1001652. doi: 10.1371/journal.pbio.1001652. Epub 2013 , Sep 10. PMID:24058294 doi:10.1371/journal.pbio.1001652

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