4cct

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Template:STRUCTURE 4cct

Contents

Dengue 1 cryo-EM reconstruction

Template:ABSTRACT PUBMED 23637416

Function

[G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

About this Structure

4cct is a 6 chain structure with sequence from Dengue virus 1. This structure supersedes the now removed PDB entry 4azx. Full crystallographic information is available from OCA.

Reference

  • Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM. Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416 doi:10.1128/JVI.00197-13

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